Survival Of Patients With Brain Metastases After Palliative Whole-Brain Radiotherapy - An Experience From A Single...

Area of Science:

• Oncology
• Radiotherapy
• Cancer Metastasis

Background:

• Brain metastases affect approximately 20% of cancer patients.
• Palliative whole-brain radiotherapy is a cost-effective treatment for multiple brain metastases.
• This study evaluates survival and prognostic factors in patients receiving palliative whole-brain radiotherapy.

Purpose of the Study:

• Determine overall survival in patients with brain metastases treated with palliative whole-brain radiotherapy.
• Identify prognostic factors influencing survival in this patient population.

Main Methods:

• Cross-sectional, retrospective study of patients who completed palliative whole-brain radiotherapy (July 2015 - July 2020).
• Data analyzed using SPSS 21.0.
• Overall survival calculated using the Kaplan-Meier method.

Main Results:

• Breast cancer was the most common primary tumor (45%), followed by lung (16.3%) and genitourinary (15.5%) cancers.
• Median overall survival was 5 months for breast cancer patients and 7 months for lung cancer patients.
• Patients with extracranial disease had a median survival of 5 months, compared to 12 months for those without.

Conclusions:

• Breast cancer is the most frequent cause of brain metastases.
• Younger patients, particularly those with triple-negative breast cancer, had poorer prognoses.
• Controlling extracranial disease significantly improved overall survival for patients with brain metastases.