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Sequence Sensitivity in Membrane Remodeling by Polyampholyte Condensates.

Sayantan Mondal1, Qiang Cui1,2,3

  • 1Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

The Journal of Physical Chemistry. B
|February 26, 2024
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Summary
This summary is machine-generated.

Intrinsically disordered peptides (IDPs) form condensates that interact with cell membranes. Stronger IDP condensates remodel membranes by inducing curvature and lipid demixing, while weaker ones wet the membrane surface.

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Soft Matter Physics

Background:

  • Intrinsically disordered peptides (IDPs) undergo liquid-liquid phase separation (LLPS) forming coacervates with regulatory cellular roles.
  • LLPS near membranes aids biomolecular organization and signaling but its molecular mechanisms are unclear.

Purpose of the Study:

  • Investigate the effects of polyampholyte and polyelectrolyte condensation on anionic membranes.
  • Elucidate the molecular mechanisms of membrane remodeling and wetting by IDP condensates.

Main Methods:

  • Calibrated MARTINI v3.0 force field for simulations.
  • Performed long-timescale coarse-grained molecular dynamics simulations.
  • Analyzed condensate-membrane interactions and energetics.

Main Results:

  • All polyampholyte condensates adsorbed to the membrane.
  • Strong polyampholytes (blocky sequences) induced significant negative membrane curvature and lipid demixing.
  • Weaker polyampholytes (scrambled sequences) primarily wetted the membrane without significant curvature induction.

Conclusions:

  • Polyampholyte sequence affects condensate behavior and membrane interaction.
  • Membrane remodeling and wetting are driven by favorable interactions between polyampholytes, lipids, and counterions.
  • Understanding these interactions is key to IDP-mediated cellular organization.