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Related Experiment Video

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Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents

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A Bioimpedance Spectroscopy Interface for EIM Based on IF-Sampling and Pseudo 2-Path SC Bandpass ∆Σ ADC.

Alejandro D Fernandez Schrunder, Yu-Kai Huang, Saul Rodriguez

IEEE Transactions on Biomedical Circuits and Systems

|February 26, 2024

Summary

This study introduces a low-noise bioimpedance spectroscopy interface for electrical impedance myography. The system accurately detects muscle contractions, showing potential for wearable EIM devices.

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Area of Science:

Biomedical Engineering
Electrical Engineering
Signal Processing

Background:

Electrical Impedance Myography (EIM) requires accurate bioimpedance measurements.
Existing interfaces face challenges in noise, power efficiency, and data throughput for detecting muscle contractions.

Purpose of the Study:

To present a novel low-noise bioimpedance spectroscopy interface for EIM.
To achieve high accuracy and efficiency in bioimpedance readings across a wide frequency range.
To demonstrate the interface's capability for detecting muscle activity.

Main Methods:

Utilized a direct-digital-synthesis (DDS) sinusoidal signal generator for accurate bioimpedance readings.
Employed a quadrature low-intermediate frequency (IF) readout with low-gain IAs and bandpass ∆Σ ADCs.
Implemented the interface in a 180 nm CMOS process.

Main Results:

Achieved 0.7 mΩ/Hz sensitivity at 15.625 kHz and 105.8 dB SNR within a 4 Hz bandwidth.
Demonstrated a figure-of-merit of 146.5 dB, indicating excellent performance.
Successfully recorded EIM data during bicep brachii muscle contractions.

Conclusions:

The proposed bioimpedance spectroscopy interface offers a low-noise, efficient solution for EIM.
The system's performance is suitable for detecting muscle contractions in real-time.
This technology holds significant potential for developing advanced wearable EIM systems.