Related Experiment Video
Updated: Jun 7, 2026

11:22
Automated Robotic Liquid Handling Assembly of Modular DNA Devices
Published on: December 1, 2017
12.4K
Opto-fluidically multiplexed assembly and micro-robotics
Elena Erben1,2,3, Weida Liao4, Antonio Minopoli1,2
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany.
Light, Science & Applications
|February 26, 2024
Summary
This study introduces laser-induced flow fields for precise micro-particle manipulation, overcoming limitations of optical tweezers and traditional microfluidics. This novel method enables high-definition microfluidic control for diverse applications.
Area of Science:
- Microfluidics
- Optics
- Robotics
- Materials Science
Background:
- Existing high-definition micromanipulation techniques like optical tweezers are limited by material properties and laser damage.
- Microfluidic manipulations offer an alternative but face practical control and implementation challenges.
- Current methods struggle with precise, material-independent manipulation of micro-particles.
Purpose of the Study:
- To develop a novel method for high-definition micromanipulation of micro-particles.
- To overcome the limitations of existing techniques regarding material properties and laser exposure.
- To demonstrate advanced microfluidic control capabilities for complex tasks.
Main Methods:
- Iterative application of laser-induced, localized flow fields for particle positioning.
- Utilized multiplexed temperature stimuli below the heat diffusion limit to accelerate manipulation precision.
- Characterized topologically rich and mathematically predictable flow fields.
Main Results:
- Achieved material-independent relative positioning of multiple micro-particles.
- Demonstrated non-linear acceleration of precision manipulation through temperature multiplexing.
- Successfully actuated humanoid micro-robots with up to 30 degrees of freedom, conveying complex characteristics.
Conclusions:
- The developed method offers unprecedented microfluidic control capabilities.
- This technique enables high-definition micro-fluidic manipulations with transformative potential.
- Applications span assembly, micro-manufacturing, life sciences, robotics, and micro-factories.
Related Concept Videos
Composite Bodies
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Two Components: Liquid–Liquid Systems
A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...
Mechanical Systems
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically described...
Electro-mechanical Systems
Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
Transformers in Distribution System
Transformers in distribution systems can be broadly categorized into distribution substation transformers and other distribution transformers. They are crucial for stepping down high transmission voltages to levels suitable for distribution and end-user applications.
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...
Laminar Flow
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:

