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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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Published on: February 13, 2016

3D-Printed Multifunctional Multicompartment Polymer-Based Capsules for Tunable and Spatially Controlled Drug Release.

Antonio Minopoli^1,2, Giordano Perini^1,2, Davide Evangelista^1,2

¹Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.

Journal of Functional Biomaterials

|December 24, 2025

Summary

This summary is machine-generated.

This study introduces a 3D printing method to create advanced polymer drug delivery capsules. These multicompartment capsules offer precise, site-specific drug release for targeted intestinal delivery.

Keywords:

3D printing biopolymer-based capsules controlled drug release edible hydrogels enteric coating essential oil oil microemulsion

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Published on: October 8, 2021

Area of Science:

Polymer Science
Materials Science
Biomedical Engineering

Background:

Polymer-based systems are crucial for developing advanced drug delivery carriers due to their tunable properties.
Designing complex, responsive drug delivery systems remains a significant challenge in pharmaceutical research.

Purpose of the Study:

To develop a novel 3D printing strategy for fabricating multicompartment polymer capsules.
To achieve precise spatial organization and structural complexity in drug delivery carriers.
To enable customizable, localized, and site-specific drug release.

Main Methods:

Fabrication of multicompartment capsules using a one-step 3D printing process.
Integration of multiple polymers within the capsule structure.
Programming pH-triggered release across distinct polymeric regions.

Main Results:

Successful creation of structurally complex, multicompartment capsules.
Demonstration of customizable features including compartmentalization and polymer-specific responsiveness.
Achieved localized, pH-triggered drug release for site-specific delivery in intestinal segments.

Conclusions:

3D printing offers a scalable and adaptable platform for producing multifunctional polymer-based carriers.
This approach enables finely tunable drug release profiles for controlled delivery.
Paves the way for new directions in polymer-enabled controlled drug delivery technologies.