Objectively measured peri-vaccination sleep does not predict COVID-19 breakthrough infection.

Area of Science:

• Sleep science
• Vaccinology
• Epidemiology

Background:

• Previous research indicates sleep duration around vaccination influences antibody response.
• The effect of peri-vaccination sleep on real-world vaccine effectiveness remains largely unknown.

Purpose of the Study:

• To investigate the association between objectively measured sleep patterns and COVID-19 breakthrough infection rates.
• To determine if sleep duration, efficiency, or awakening frequency predict infection post-vaccination.

Main Methods:

• The DETECT study utilized digital recruitment and activity trackers for objective sleep data.
• Logistic regression and Cox proportional hazards models analyzed sleep metrics against breakthrough infections, controlling for age and gender.
• Breakthrough infections after the second vaccine dose and first booster were assessed.

Main Results:

• No significant difference in sleep duration was observed between individuals with and without breakthrough infections.
• Increased frequency of awakenings during sleep was associated with a higher risk of breakthrough infection after the first COVID-19 booster.
• Age under 60 and higher awakening frequency independently predicted breakthrough infection following the first booster dose.

Conclusions:

• While sleep duration did not correlate with breakthrough infections, increased sleep awakenings may be a risk factor.
• The clinical significance of heightened awakening frequency on vaccine effectiveness requires further investigation.