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Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Related Experiment Video

Updated: Jun 8, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
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Percutaneous Left Ventricular Unloading During High-Risk Coronary Intervention: Rationale and Design of the

Matthew Ryan1, Saad M Ezad1, Ian Webb2

  • 1School of Cardiovascular and Metabolic Medicine & Sciences at the British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (M.R., S.M.E., H.R., D.P.).

Circulation. Cardiovascular Interventions
|February 27, 2024
PubMed
Summary

This trial investigates if percutaneous left ventricular unloading reduces adverse events in high-risk coronary intervention patients. Results will guide treatment for complex coronary artery disease and impaired heart function.

Keywords:
coronary artery diseaseheart-assist devicesleft ventricular systolic dysfunctionpercutaneous coronary interventionrandomized controlled trial

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • High-risk percutaneous coronary intervention (PCI) for complex coronary artery disease carries a significant risk of cardiogenic shock.
  • Impaired left ventricular (LV) function exacerbates risks during PCI, potentially limiting revascularization quality.
  • Percutaneous LV unloading is explored to mitigate adverse events, but lacks robust evidence and incurs costs.

Purpose of the Study:

  • To evaluate the efficacy of elective percutaneous LV unloading versus standard care in high-risk PCI patients.
  • To determine if LV unloading improves outcomes in patients with severe LV systolic dysfunction and extensive coronary artery disease.
  • To assess the impact of LV unloading on a composite of major adverse cardiovascular events.

Main Methods:

  • A prospective, multicenter, open-label randomized controlled trial (CHIP-BCIS3).
  • Recruitment of patients with severe LV dysfunction, extensive coronary artery disease undergoing complex PCI (excluding cardiogenic shock/STEMI).
  • Primary outcome: hierarchical composite of death, stroke, MI, hospitalization, and periprocedural MI analyzed by win ratio.

Main Results:

  • 169 patients recruited from 21 UK NHS hospitals to date.
  • Recruitment is ongoing, with completion expected in 2024.
  • The study is powered to detect a hazard ratio of 0.62 with 150 events.

Conclusions:

  • The CHIP-BCIS3 trial is actively recruiting patients for this important investigation.
  • Findings will provide crucial evidence on the effectiveness of percutaneous LV unloading in high-risk PCI.
  • The study aims to optimize patient outcomes and revascularization strategies in complex coronary disease.