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Baseline Participant Characteristics at Enrollment in the Zoster Eye Disease Study
Christina R Prescott1, Elisabeth J Cohen1, Judith S Hochman2
1Departments of Ophthalmology.
Cornea
|February 27, 2024
Summary
The Zoster Eye Disease Study (ZEDS) evaluated long-term valacyclovir for herpes zoster ophthalmicus (HZO). This trial
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Background:
- Herpes zoster ophthalmicus (HZO) can lead to significant ocular complications.
- Long-term suppressive antiviral therapy is being investigated for HZO management.
- The Zoster Eye Disease Study (ZEDS) is a key trial in this area.
Purpose of the Study:
- To assess the efficacy of 1-year suppressive valacyclovir treatment for herpes zoster ophthalmicus (HZO) outcomes.
- To detail the baseline characteristics of participants in the ZEDS trial.
- To provide generalizable evidence on valacyclovir's role in HZO care.
Main Methods:
- A randomized, double-masked, placebo-controlled trial.
- Enrollment of 527 immunocompetent adults with a history of HZO and ocular inflammation.
- Randomization to daily oral valacyclovir (1 gm) or placebo for 1 year, with 18-month follow-up.
Main Results:
- 527 participants were enrolled across defined strata (age, HZO duration).
- A majority had recent HZO (57%) and were younger than 60 (54%).
- Most received acute antiviral treatment (91%) and were unvaccinated (79%).
Conclusions:
- The ZEDS study population is broad, enhancing generalizability.
- Findings will inform the efficacy and safety of suppressive valacyclovir for HZO.
- Results may determine if valacyclovir becomes a standard of care for HZO.
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