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Updated: Jul 2, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Kidney Function in Hypertensive Patients with Left Ventricular Hypertrophy
I N Mba1, B Basil2, B Myke-Mbata2
1Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria.
Insights
Hypertensive patients with left ventricular hypertrophy (LVH) showed better kidney function, indicated by lower microalbuminuria and reduced chronic kidney disease (CKD) stages, compared to those without LVH.
Area of Science:
- Nephrology
- Cardiology
- Hypertension Research
Background:
- Hypertension-induced kidney impairment increases morbidity and mortality.
- Left ventricular hypertrophy (LVH) is a common hypertension complication that can worsen patient outcomes.
- Understanding the relationship between LVH and kidney function in hypertensive patients is crucial.
Purpose of the Study:
- To compare kidney function in hypertensive patients with LVH versus those without LVH.
- To investigate the impact of LVH on markers of kidney damage in hypertension.
Main Methods:
- Study conducted in Nigerian tertiary hospitals among hypertensive patients.
- Demographic and clinical data collected via questionnaire.
- Kidney function assessed by serum urea, creatinine, urinary creatinine, and microalbumin.
- Echocardiography used to diagnose LVH.
Main Results:
- LVH was present in 45.7% of 105 participants.
- Patients with LVH were older and had lower weight.
- Contrary to expectations, patients without LVH exhibited higher microalbuminuria (p=0.03) and lower estimated glomerular filtration rate (eGFR) (p=0.004), suggesting more advanced CKD stages.
Conclusions:
- Hypertensive patients with LVH demonstrated better kidney function markers, including lower microalbuminuria and higher eGFR.
- These findings suggest a potentially protective effect or different disease pathway in hypertensive patients with LVH regarding kidney function.
- Further research is needed to elucidate the mechanisms behind these observed differences in kidney function.
Background:
Impairment of kidney function is one of the long-term sequelae of hypertension and it contributes to increased morbidity and mortality in hypertensive patients. Left ventricular hypertrophy (LVH) is a common complication of hypertension which can worsen the outcome in affected patients. This study was designed to compare kidney function in hypertensive patients with LVH with that in hypertensive patients without LVH.
Methods:
The study was conducted among hypertensive patients attending cardiology clinics at two tertiary hospitals in Nigeria. A questionnaire was used to obtain demographic and clinical information from the participants. Kidney function was determined by measuring serum urea and creatinine, urinary creatinine and microalbumin. Echocardiography was performed to detect LVH. Results of kidney function tests were compared between participants who had LVH and those who did not.
Results:
Of the 105 participants recruited, 58 (55.2%) were males. The median age of all participants was 52 (interquartile range (IQR) 40-61) years and LVH was confirmed in 48 (45.7%) of them. Participants with LVH were older (55 vs 49 years; p=0.02) but had lower weight (74 vs 78 kg; p=0.04). Participants without LVH had higher microalbuminuria (5.2 vs 4.05 mg/dl; p=0.03), lower estimated glomerular filtration rate (62 vs 92 ml/min/1.73 m2; p=0.004), and higher stages of CKD.
Conclusion:
Hypertensive patients with LVH had lower levels of microalbuminuria, higher estimated GFR, and lower stages of CKD compared to those with no LVH.
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