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Risk factors for isolated atrial septal defect secundum morbidity
Gustaf Tanghöj1, Estelle Naumburg2
1Unit of Pediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden.
Insights
Premature birth is not a risk factor for cardiac issues in children with isolated atrial septal defect secundum (ASD II). Down syndrome, however, was linked to increased cardiac morbidity in these children.
Area of Science:
- Pediatrics
- Cardiology
- Congenital Heart Defects
Background:
- Atrial septal defect secundum (ASD II) is a common congenital heart defect, particularly in premature infants.
- Understanding risk factors for cardiac morbidity in children with ASD II is crucial for effective management.
Purpose of the Study:
- To investigate whether premature birth is associated with increased cardiac morbidity in children diagnosed with isolated ASD II.
- To identify independent risk factors for cardiac morbidity in this pediatric population.
Main Methods:
- Retrospective national registry-based case-control study.
- Inclusion of children born in Sweden (2010-2015) with isolated ASD II.
- Conditional logistic regression analysis with adjustments for confounding factors.
Main Results:
- 11% of children with isolated ASD II required treatment for heart failure.
- Down syndrome was identified as the sole independent risk factor for cardiac morbidity (OR = 2.25).
- Premature birth was not significantly associated with increased cardiac morbidity in children with isolated ASD II.
Conclusions:
- Premature birth does not appear to be an independent risk factor for cardiac morbidity in children with isolated ASD II.
- Down syndrome is a significant risk factor for cardiac morbidity in children with ASD II.
- Further research may explore other potential contributing factors to cardiac morbidity in this cohort.
Abstract:
Atrial septal defect secundum is a common type of congenital heart defect and even more common among children born premature. The aim of this study was to assess premature birth as a potential associated risk factors for cardiac morbidity in children with isolated ASD II. In this retrospective national registry-based case-control study all children born in Sweden between 2010 and 2015 with an isolated ASD II diagnosis were included. Association between premature birth and cardiac morbidity in children with isolated ASD II was assessed by different outcomes-models using conditional logistic regression and adjustments were made for confounding factors. Overall, 11% of children with an isolated ASD II received treatment for heart failure. Down syndrome was the only independent risk factors for associated with cardiac morbidity in children with ASD II (OR = 2.25 (95%CI 1.25-4.07). Preterm birth in children was not associated with an increased risk of ASD II cardiac morbidity.
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