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Updated: Jun 16, 2026

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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
Published on: November 20, 2011
11.6K
The OrganiX microfluidic system to recreate the complex tumour microenvironment
Giulia Adriani1,2, Andrea Pavesi3,4
1Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. giulia_adriani@immunol.a-star.edu.sg.
Nature Reviews. Immunology
|February 27, 2024
Summary
No abstract available in PubMed .
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The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...