Related Experiment Video
Updated: Jul 2, 2025
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
20.7K
Synergistic modelling of human disease.
Julija Hmeljak1, Kirsty M Hooper1
1The Company of Biologists, Bidder Building, Station Road, Histon, Cambridge CB24 9LF, UK.
Disease Models & Mechanisms
|February 28, 2024
Summary
Living model systems are essential for disease research but have limitations. Understanding these challenges is crucial for advancing biological insights and developing effective disease models.
Area of Science:
- * Disease biology research
- * Development of living model systems
Background:
- * Living model systems, from bacteria to primates, are fundamental in disease biology.
- * The scientific community acknowledges inherent challenges and limitations in individual disease models.
- * The quote ‘All models are wrong, but some are useful’ highlights the imperfect nature of these systems.
Purpose of the Study:
- * To discuss the utility and limitations of diverse living model systems in disease research.
- * To emphasize the ongoing need for critical evaluation of model systems in biology.
Main Methods:
- * Review of established principles in disease modeling.
- * Discussion of the spectrum of living model systems used in research.
- * Analysis of the implications of model system limitations.
Main Results:
- * Living model systems offer valuable insights but are not without flaws.
- * No single model system is universally applicable or perfect for all research questions.
- * The selection and interpretation of data from model systems require careful consideration.
Conclusions:
- * Living model systems are indispensable tools in disease biology, despite their limitations.
- * A nuanced understanding of model system strengths and weaknesses is vital for scientific progress.
- * The judicious use of appropriate models is key to advancing our understanding of diseases.
Related Concept Videos
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
01:23Mechanistic Models: Compartment Models in Individual and Population Analysis
40
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
40
01:11Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
01:21EPS and iPS Cells in Disease Research
2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K