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Multiple cutaneous and uterine leiomyomatosis: Reed's syndrome
Dibyendu Bikash Bhanja1, Abheek Sil1, Bartika Sikder1
1Dermatology, Venereology and Leprosy, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.
Reed's syndrome (RS) is a rare genetic disorder causing multiple tumors. Early detection in families with uterine fibroids is key for managing cancer risks.
Area of Science:
- Genetics
- Oncology
- Dermatology
Background:
- Reed's syndrome (RS) is an autosomal-dominant disorder.
- Characterized by multiple cutaneous and uterine leiomyomas.
- Associated with a high risk of renal cell carcinoma (RCC).
Observation:
- A woman in her 50s presented with painful cutaneous leiomyomas.
- She had a history of uterine leiomyomas and hysterectomy.
- Diagnosis was confirmed via histopathology and family history.
Findings:
- Clinicopathological correlation established the diagnosis of Reed's syndrome.
- Early-onset uterine leiomyomas in a family history suggest RS.
- Mandatory renal imaging is required for RCC detection.
Implications:
- Vigilant long-term follow-up is necessary for RS patients.
- Screening family members is crucial for early diagnosis.
- Genetic counseling is essential for affected families.
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