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MiR-128-3p - a gray eminence of the human central nervous system
Klaudia Kiel1, Sylwia Katarzyna Król2, Agnieszka Bronisz1
1Tumor Microenvironment Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Street, Warsaw, Poland.
Abstract:
MicroRNA-128-3p (miR-128-3p) is a versatile molecule with multiple functions in the physiopathology of the human central nervous system. Perturbations of miR-128-3p, which is enriched in the brain, contribute to a plethora of neurodegenerative disorders, brain injuries, and malignancies, as this miRNA is a crucial regulator of gene expression in the brain, playing an essential role in the maintenance and function of cells stemming from neuronal lineage. However, the differential expression of miR-128-3p in pathologies underscores the importance of the balance between its high and low levels. Significantly, numerous reports pointed to miR-128-3p as one of the most depleted in glioblastoma, implying it is a critical player in the disease's pathogenesis and thus may serve as a therapeutic agent for this most aggressive form of brain tumor. In this review, we summarize the current knowledge of the diverse roles of miR-128-3p. We focus on its involvement in the neurogenesis and pathophysiology of malignant and neurodegenerative diseases. We also highlight the promising potential of miR-128-3p as an antitumor agent for the future therapy of human cancers, including glioblastoma, and as the linchpin of brain development and function, potentially leading to the development of new therapies for neurological conditions.
Insights
MicroRNA-128-3p is vital for brain function and development. Its depletion is linked to glioblastoma, suggesting its potential as a therapeutic agent for brain tumors and neurological disorders.
Area of Science:
- Neuroscience
- Molecular Biology
- Oncology
Background:
- MicroRNA-128-3p (miR-128-3p) is a key regulator of gene expression in the human central nervous system.
- Dysregulation of miR-128-3p is implicated in neurodegenerative diseases, brain injuries, and cancers.
- miR-128-3p is notably depleted in glioblastoma, a highly aggressive brain tumor.
Purpose of the Study:
- To review the multifaceted roles of miR-128-3p in neurogenesis and disease.
- To explore the potential of miR-128-3p as a therapeutic target for neurological conditions and cancers.
- To highlight miR-128-3p's significance in brain development and function.
Main Methods:
- Literature review of existing studies on miR-128-3p.
- Analysis of miR-128-3p's involvement in cellular and molecular pathways.
- Synthesis of data on miR-128-3p's role in disease pathogenesis and therapeutic potential.
Main Results:
- miR-128-3p plays a critical role in maintaining neuronal lineage cells and brain function.
- Altered levels of miR-128-3p are associated with various neuropathologies, including glioblastoma.
- miR-128-3p exhibits potential as a biomarker and therapeutic agent for brain cancers.
Conclusions:
- miR-128-3p is essential for normal brain development and function.
- Its dysregulation contributes to the pathogenesis of malignant and neurodegenerative diseases.
- Targeting miR-128-3p offers promising therapeutic strategies for glioblastoma and other neurological disorders.
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