Renogram evaluation using an equation of balance for clearance and transit time determination

A method of [123I]hippuran (OIH) renogram evaluation is proposed, which delivers transition rates for total and split renal clearance. It is based on the reconstruction of the true kidney input, using an equation of balance and a two-compartment model assumption of OIH kinetics. Results are compared with clearance determinations using whole body principles and transit time determination by deconvolution. It is shown that the reconstructed true input corresponds to the plasma activity while the vascular volume of distribution corresponds to the blood.