Matrix Metalloproteinase-9 Testing of Golden Rice Cookies With Piper Crocatum Active Extract for Preventing Foot...

Area of Science:

• Nutritional Science
• Biochemistry
• Clinical Medicine

Background:

• Diabetic foot ulcers (DFUs) are a major complication of diabetes, leading to significant morbidity and amputations.
• Effective prevention strategies are crucial, focusing on blood sugar control and complication management.
• Piper crocatum (P. crocatum) and Golden Rice show potential in managing diabetes risk factors.

Purpose of the Study:

• To evaluate the efficacy of P. crocatum-enriched Golden Rice cookies in preventing DFUs.
• To assess the impact of these cookies on matrix metalloproteinase-9 (MMP-9) expression, a key factor in DFU development.

Main Methods:

• A randomized controlled trial with a single-blind design was conducted.
• Participants diagnosed with diabetes consumed either P. crocatum-enriched Golden Rice cookies or control cookies for 14 days.
• Matrix metalloproteinase (MMP) expression was measured using western blotting pre- and post-intervention.

Main Results:

• Recruitment and testing began in January 2024, with completion anticipated by March 2024.
• Data analysis and publication are expected in 2024.
• Changes in MMP expression, ankle-brachial index, neuropathy score, and blood glucose levels will be reported.

Conclusions:

• The study is expected to provide insights into therapeutic snacking for diabetes self-management.
• Findings may influence healthcare practitioners' strategies for DFU prevention.