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Updated: Jun 22, 2026
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Transient resting-state salience-limbic co-activation patterns in functional neurological disorders
Samantha Weber1, Janine Bühler2, Serafeim Loukas3
1Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, 3012 Bern, Switzerland; University of Zurich, Psychiatric University Hospital Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, 8032 Zurich, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, 3010 Bern, Switzerland; Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Functional neurological disorder patients show altered brain network dynamics, particularly in the salience-limbic network. These changes correlate with stress biomarkers and symptom duration, suggesting impaired stress regulation and network integration.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Functional neurological disorders (FND) were historically linked to stress but lacked direct testing.
- Investigating brain network dynamics and stress biomarkers could elucidate FND pathophysiology.
Purpose of the Study:
- To analyze large-scale brain network dynamics at rest in FND patients.
- To examine the relationship between these dynamics, stress biomarkers (cortisol, amylase), and clinical symptoms.
Main Methods:
- Resting-state fMRI in 79 FND patients and 74 controls.
- Hierarchical analysis of static and dynamic functional connectivity between 17 resting-state networks.
- Partial least squares correlation to link network alterations with biomarkers and clinical scores.
Main Results:
- FND patients exhibited aberrant salience-limbic network connectivity, with altered insular co-activation patterns.
- Patients showed increased engagement with salience, somatomotor, and default mode networks, and decreased engagement with subcortical and diverse cortical networks.
- Dynamic network alterations correlated with amylase levels and symptom duration in patients.
Conclusions:
- Altered insular co-activation patterns, stress biomarkers, and clinical data suggest interconnected mechanisms in stress regulation and functional network integration.
- Findings support concepts of impaired attentional and interoceptive processing in FND.
- Dynamic functional brain network alterations are identified in FND, offering new pathophysiological insights.
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