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Neutrophilic Urticarial Dermatosis
Amarachi Orakwue1, Jeremy Bray2, Nneka Comfere3
1University of Minnesota Medical School, 420 Delaware Street Southeast Suite C607, Minneapolis, MN 55455, USA.
Dermatologic Clinics
|February 29, 2024
Summary
Neutrophilic urticarial dermatosis (NUD) is a rare skin condition characterized by specific neutrophilic infiltrates. This poorly understood dermatosis presents as transient, nonpruritic lesions often linked to systemic diseases.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Neutrophilic urticarial dermatosis (NUD) is a rare and poorly understood dermatosis.
- NUD was first described as an urticarial eruption with specific histopathological features.
Purpose of the Study:
- To summarize the key characteristics of Neutrophilic urticarial dermatosis.
- To highlight the clinical and histopathological findings of NUD.
- To outline associated systemic conditions linked to NUD.
Main Methods:
- Literature review of NUD cases.
- Histopathological analysis of skin biopsies.
- Clinical case study analysis.
Main Results:
- NUD histopathology shows perivascular/interstitial neutrophilic infiltrate with leukocytoclasia, excluding vasculitis or edema.
- Clinically, NUD presents as chronic or recurrent nonpruritic macules, papules, or plaques.
- Lesions are pink to reddish, resolve within 24 hours, and lack residual pigmentation.
Conclusions:
- NUD is a distinct neutrophilic dermatosis with characteristic clinical and histopathological findings.
- The condition is often associated with systemic diseases, including Schnitzler syndrome and autoimmune disorders.
- Further research is needed to fully elucidate the pathogenesis and optimal management of NUD.
