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Peroxisome-based metabolic engineering for biomanufacturing and agriculture
Shuyan Song1, Cuifang Ye1, Yijun Jin1
1State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China.
Trends in Biotechnology
|February 29, 2024
Summary
Peroxisome engineering in yeast and plants shows great promise for biological manufacturing and agriculture. This review highlights achievements and strategies for improving engineered metabolic pathways within peroxisomes.
Area of Science:
- Metabolic Engineering
- Synthetic Biology
- Cellular Compartmentalization
Background:
- Subcellular compartmentalization is key for efficient metabolic engineering.
- The peroxisome is a promising organelle for engineering biological systems.
- Applications span biological manufacturing and agricultural advancements.
Purpose of the Study:
- To review peroxisome engineering achievements in yeast and plants.
- To outline strategies for enhancing engineered peroxisomal pathways.
- To discuss future prospects in peroxisome engineering.
Main Methods:
- Literature review of peroxisome engineering studies.
- Analysis of successful biocompound production in engineered yeast.
- Examination of progress in plant peroxisome engineering.
Main Results:
- Significant progress has been made in engineering yeast peroxisomes for biocompound production.
- Plant peroxisome engineering demonstrates high potential for biomanufacturing and agriculture.
- Various validated strategies exist to optimize engineered peroxisomal pathways.
Conclusions:
- Peroxisome engineering is a powerful tool for metabolic engineering in yeast and plants.
- Optimized peroxisomal pathways offer substantial benefits for biomanufacturing and agriculture.
- Further research into peroxisome engineering holds significant promise for future applications.
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