Changes in brain cholesterol and its regional distribution under the influence of prednisolone

Male albino rats were studied for effect of prednisolone on brain cholesterol and water content. Oral administration of prednisolone (5 mg/kg rat/day for 21 days) results in reduction of brain weight and brain cholesterol content but no change in brain water content was seen. The reduction of cholesterol may be the cause of disorders found in neural functions in conditions of glucocorticoid excess.