Related Experiment Video
Updated: Jul 1, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Two new cassane diterpenoids from the seed kernels of Caesalpinia sinensis
Lian Lian1, Yue-Lin Zhao2,3, Tian-Jian Zhang2,3
1School of Biopharmaceutical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi 117004, China.
Abstract:
Two new cassane diterpenoids, sucupiranin MN (1) and sucupiranin ML (2), together with two known compounds sucutinirane C (3) and deacetylsucutinirane C (4) were isolated from the seed kernels of Caesalpinia sinensis. Their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially HRESIMS and 1D/2D NMR spectroscopy. Compounds 1-4 are typical furan-type cassane derivatives with an aromatized C ring. Biological evaluation revealed that compounds 1-4 at the concentration of 10 μM could inhibit the overproduction of NO in LPS-stimulated RAW 264.7 macrophages.

