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Monoclonal antibody patterns in lymphomatoid papulosis
Dermatologic Clinics
|October 1, 1985
Summary
Atypical cells in lymphomatoid papulosis express the Ki-1 antigen, similar to Reed-Sternberg cells in Hodgkin's disease. These findings suggest these cells are activated T cells, closely related to those found in Hodgkin's disease.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Oncology
Background:
- Lymphomatoid papulosis (LyP) exhibits atypical cells that resemble Reed-Sternberg cells.
- The precise nature and antigenic relationship of these LyP cells to Reed-Sternberg cells remain unclear.
Purpose of the Study:
- To investigate the immunophenotype of atypical cells in LyP.
- To determine the antigenic relationship between LyP cells and Reed-Sternberg cells.
Main Methods:
- Immunohistochemical analysis of 24 LyP biopsy specimens using antibodies against Ki-1 and other Reed-Sternberg cell-associated antigens.
- Comparison with 20 biopsy specimens of benign inflammatory skin lesions and mycosis fungoides.
Main Results:
- A proportion of large, atypical cells in all LyP cases expressed the Ki-1 antigen.
- Ki-1-positive cells were absent or rare in benign inflammatory lesions and mycosis fungoides.
- LyP cells expressed T3, T4, HLA-DR, and IL-2 receptors, antigens also found on Reed-Sternberg cells.
Conclusions:
- The Ki-1-positive cells in LyP are activated T cells.
- These activated T cells show a close antigenic relationship to Reed-Sternberg cells of Hodgkin's disease.