Urinary protein and coagulation-fibrinolysis indicators in preeclampsia: Expression and significance

Area of Science:

• Obstetrics and Gynecology
• Clinical Chemistry
• Hematology

Background:

• Preeclampsia is a serious pregnancy complication characterized by high blood pressure and organ damage.
• Understanding the role of urinary protein and coagulation markers is crucial for managing preeclampsia.
• Distinguishing between mild and severe preeclampsia is essential for appropriate clinical intervention.

Purpose of the Study:

• To investigate the expression and significance of urinary protein and coagulation-fibrinolysis indicators in preeclampsia.
• To compare these indicators across mild preeclampsia, severe preeclampsia, and gestational hypertension groups.
• To identify factors influencing adverse maternal and infant outcomes in severe preeclampsia.

Main Methods:

• Comparative analysis of 109 mild preeclampsia, 97 severe preeclampsia, and 110 gestational hypertension cases.
• Collection and analysis of general information, laboratory indicators, urinary protein levels, and coagulation-fibrinolysis indicators.
• Statistical analysis to identify significant differences and influencing factors.

Main Results:

• Significant differences in blood pressure were observed across groups.
• Severe preeclampsia showed higher total cholesterol, triglycerides, and LDL, with lower HDL, albumin, and platelets compared to mild preeclampsia and gestational hypertension.
• Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse outcomes in severe preeclampsia.

Conclusions:

• Urinary protein and coagulation-fibrinolysis indicators are elevated in preeclampsia, particularly in severe cases.
• These markers show potential as diagnostic influencing factors for severe preeclampsia.
• Further research can explore their utility in predicting adverse maternal and infant outcomes.