"In vitro" study on human mononuclear phagocytic cells behaviour versus DNA and RNA viruses

It is generally accepted that mononuclear phagocytic cells are of crucial importance in defence against viral infections. Using a method of "in vitro" differentiation from human blood monocytes to macrophages, the interactions between human monocyte-macrophage with herpes simplex virus type 1 and 2, adenovirus type 17, coxsackie virus B type 4, poliovirus type 1 and ECHO virus type 2, are reported. In all viruses tested on monocytes, the infection of the cells was very poor according to the data of specific immunofluorescence and of the residual infectivity. In the macrophage stage all viruses tested were able to infect the cells.