Internal absorbed dose calculation in body organs due to injection of Rhenium-188 labeled to Mu-9 antibody

The use of radiopharmaceuticals has gained a special place in the diagnosis and treatment of cancers and evaluation of the function of different organs of the body. In this study, the absorbed dose distribution of organs after injection of ¹⁸⁸Re-Mu-9 has been investigated using MIRD method and MCNP-4C simulation code. The ¹⁸⁸Re-Mu-9 labeled was injected the mouse body and the amount of ¹⁸⁸Re-labeled accumulation was evaluated after 1, 4 and 2 4 h. Having a map of the distribution of radiopharmaceutical activity in the animal body, it is possible to convert it into a human model to obtain the internal dose received by ¹⁸⁸Re-Mu-9 injection using the MIRD calculation method and the MCNP simulation code. According to the results of the study, the animal/human model can be acceptable method for dose estimation of antibody-based radiopharmaceuticals.