Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Outcomes of Leadless Versus Transvenous Pacemakers Following Tricuspid Valve Surgery.

Journal of the American Heart Association·2026
Same author

Outcomes of Percutaneous and Surgical Interventions of Right-Sided Heart Masses in Older Patients: A Nationwide Comparative Study.

Journal of the American Heart Association·2026
Same author

Mitral Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

JACC. Cardiovascular interventions·2026
Same author

UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves: A Multicenter Study.

JACC. Cardiovascular interventions·2026
Same author

Aortic Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

JACC. Cardiovascular interventions·2026
Same author

Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.

JACC. Cardiovascular interventions·2026

Related Experiment Video

Updated: Jul 5, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.9K

Left Ventricular Outflow Tract Modification for Transcatheter Mitral Valve Replacement.

Hiroki A Ueyama1, Vasilis C Babaliaros1, Adam B Greenbaum1

  • 1Division of Cardiology, Emory Structural Heart and Valve Center, Emory University Hospital Midtown, 550 Peachtree Street, Northeast, Atlanta, GA 30306, USA.

Interventional Cardiology Clinics
|March 3, 2024
PubMed
Summary

Transcatheter mitral valve replacement carries a risk of left ventricular outflow tract (LVOT) obstruction. Pre-procedural computed tomography and LVOT modification techniques can help predict and mitigate this life-threatening complication.

Keywords:
Alcohol septal ablationLAMPOONLeft ventricular outflow tract obstructionRadiofrequency ablationSESAMETranscatheter mitral valve replacement

More Related Videos

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

2.6K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K

Related Experiment Videos

Last Updated: Jul 5, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.9K
Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

2.6K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Left ventricular outflow tract (LVOT) obstruction is a severe complication following transcatheter mitral valve replacement.
  • Accurate risk prediction is crucial for patient safety during these procedures.

Purpose of the Study:

  • To review indications, procedural steps, and outcomes of various LVOT modification techniques.
  • To highlight the role of pre-procedural computed tomography in risk assessment.

Main Methods:

  • Review of existing literature on LVOT modification strategies.
  • Analysis of computed tomography imaging for risk prediction.
  • Exploration of techniques including leaflet laceration, alcohol septal ablation, radiofrequency ablation, and septal scoring.

Main Results:

  • LVOT modification techniques are effective in mitigating obstruction risk.
  • Pre-procedural computed tomography aids in identifying patients at high risk.
  • Specific techniques like Laceration of the Anterior Mitral leaflet to Prevent Outflow ObtructioN (LAMPON) and Septal Scoring Along the Midline Endocardium (SSAME) offer targeted solutions.

Conclusions:

  • LVOT modification is a vital strategy to improve outcomes in transcatheter mitral valve replacement.
  • Personalized risk assessment using computed tomography guides the selection of appropriate LVOT modification techniques.