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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Rethinking Innovation in Drugs: A Pathway to Health for All.

Mariana Mazzucato

    The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics
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    Summary

    The US drug innovation model needs reform to align with societal needs, prioritizing public good and equitable access to medicines. Reconfiguring the market, including intellectual property, is crucial for better health outcomes.

    Keywords:
    Drug Innovation PolicyHealth EquityIntellectual Property ReformMission-Oriented GovernancePublic-Private Collaboration

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    Area of Science:

    • Health economics
    • Pharmaceutical policy
    • Innovation studies

    Background:

    • The current US drug innovation model often prioritizes profit over public health needs.
    • This misalignment can lead to high drug prices and limited access to essential medicines.

    Purpose of the Study:

    • To analyze the shortcomings of the existing US drug innovation framework.
    • To propose a revised model that better serves societal goals and ensures equitable access to health innovations.

    Main Methods:

    • Literature review of drug innovation policies.
    • Analysis of economic incentives in pharmaceutical development.
    • Examination of intellectual property law's impact on drug accessibility.

    Main Results:

    • The current model demonstrates a significant disconnect from broader societal objectives.
    • Reforms are needed to foster innovation that addresses unmet medical needs and improves affordability.

    Conclusions:

    • A mission-oriented approach is essential for reshaping the drug market.
    • Reforming intellectual property rights and market structures can promote equitable access and align innovation with the common good.