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Related Experiment Videos

CSF cortisol in affective illness.

R H Gerner, J N Wilkins

    Psychiatric Medicine
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Cerebrospinal fluid (CSF) cortisol levels are elevated in mood disorders like depression and mania, but not exclusively. These changes may reflect blood cortisol alterations, with CSF levels showing greater stability and diurnal variation.

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    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Biochemistry

    Background:

    • Previous research indicates elevated cerebrospinal fluid (CSF) cortisol in depression and mania compared to healthy individuals.
    • However, this elevation is not specific, appearing in other psychiatric and neurological conditions.
    • CSF cortisol changes are likely secondary to blood cortisol fluctuations, though CSF levels exhibit greater stability.

    Purpose of the Study:

    • To review and synthesize current findings on cerebrospinal fluid (CSF) cortisol levels in psychiatric disorders.
    • To explore the relationship between CSF cortisol and blood cortisol, as well as diurnal variations.
    • To identify limitations in current research and suggest directions for future studies.

    Main Methods:

    • Review of existing scientific literature on CSF cortisol measurements.

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  • Analysis of reported correlations between CSF and blood cortisol levels.
  • Consideration of diurnal variations and other cortisol function measures (e.g., urinary excretion, DST).

    • Main Results:

    • CSF cortisol is elevated in depression and mania, but also in other neurological and psychiatric disorders.
    • CSF cortisol levels appear more stable than blood levels and may show greater diurnal variation.
    • A significant correlation between CSF and blood cortisol found in monkeys was not observed in humans.

    Conclusions:

    • CSF cortisol elevation is a non-specific marker in psychiatric and neurological disorders.
    • Future research requires strict control for time of day, diagnostic factors, and inclusion of additional cortisol function measures.
    • The regulation of CSF cortisol and its interaction with other brain chemistries remain poorly understood.