Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A statistical model for species extrapolation using categorical response data.

R C Hertzberg, M Miller

    Toxicology and Industrial Health
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Aging in America.

    Dentistry (American Student Dental Association)·1992
    Same author

    Pneumonia associated with Salmonella choleraesuis infection in swine: 99 cases (1987-1990).

    Journal of the American Veterinary Medical Association·1992
    Same author

    Phase III trial of cyclophosphamide versus cyclophosphamide, doxorubicin, and methotrexate in hormone-refractory prostatic cancer. A Hoosier Oncology Group study.

    Cancer·1992
    Same author

    Usefulness of a CACA repeat polymorphism in genotype assignments in Duchenne/Becker muscular dystrophy.

    American journal of medical genetics·1992
    Same author

    Sadistic and self-defeating personality disorder criteria in a rural clinic sample.

    Journal of clinical psychology·1992
    Same author

    An observational study of attending rounds.

    Journal of general internal medicine·1992
    Same journal

    The history of the Toxicology Roundtable-75 years of scientific discussion.

    Toxicology and industrial health·2026
    Same journal

    Perfluorooctane sulfonate (PFOS) increases metastatic potential of thyroid cancer cells in correlation with activation of multiple invasion-related signaling proteins.

    Toxicology and industrial health·2026
    Same journal

    Biological and computational evidence of dinotefuran-DNA interactions: A combined <i>in</i> <i>vitro</i> and <i>in</i> <i>silico</i> study.

    Toxicology and industrial health·2026
    Same journal

    Dibromoacetonitrile mediated depression-like behavior in mice and induced HT22 cytotoxicity through the MKP-1/P38 MAPK signaling pathway and the antagonistic effect of N-acetylcysteine.

    Toxicology and industrial health·2026
    Same journal

    Subchronic γ-hexachlorocyclohexane exposure is associated with altered TLR4-linked pulmonary immune responses following endotoxin challenge: Insights from a two-hit mouse model.

    Toxicology and industrial health·2026
    Same journal

    Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.

    Toxicology and industrial health·2026
    See all related articles

    This study explores using the surface area model to predict human health risks from animal toxicity data for non-carcinogenic systemic effects. Statistical methods show reasonable accuracy for this dose adjustment when ample data are available.

    Area of Science:

    • Toxicology
    • Pharmacokinetics
    • Risk Assessment

    Background:

    • Human health risk predictions from animal studies necessitate interspecies adjustments.
    • Current methods include uncertainty factors or mathematical transformations to human equivalent doses.

    Purpose of the Study:

    • To investigate a generalized allometric surface area model for non-carcinogenic systemic toxicity.
    • To propose and test statistical methods for estimating the body weight power parameter.

    Main Methods:

    • Application of a generalized surface area allometric model to graded severity response data.
    • Development and testing of statistical methods for parameter estimation using simulated and real toxicity data.

    Main Results:

    Related Experiment Videos

  • The proposed statistical methods demonstrated reasonable accuracy in estimating the model's body weight power parameter.
  • Model performance is contingent on the availability of data from a large number of dose groups.

    • Conclusions:

    • The generalized surface area model shows promise for interspecies extrapolation of non-carcinogenic toxicity data.
    • Accurate risk assessment relies on robust statistical methods and sufficient dose-response data.