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Exploring the Association Between Age Groups and Success Patterns in Platelet-Rich Plasma Therapy: A Cohort Study
Shilpa Dutta1, Akash More1, Deepti Shrivastava2
1Clinical Embryology, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus
|March 4, 2024
Summary
Platelet-rich plasma (PRP) therapy shows promising results in improving endometrial thickness and clinical pregnancy rates for fertility treatments, especially in younger women. Further research is needed to understand PRP
Area of Science:
- Reproductive Medicine
- Cellular Biology
- Biotechnology
Background:
- Hormonal therapies are standard for fertility interventions.
- Platelet-rich plasma (PRP) is an emerging therapeutic option.
- The impact of patient age on PRP efficacy in fertility is not fully understood.
Purpose of the Study:
- To investigate the relationship between patient age and the success of platelet-rich plasma (PRP) therapy.
- To compare PRP therapy with conventional hormone replacement therapy (HRT) in women undergoing fertility treatments.
- To assess the effect of PRP on endometrial thickness and clinical pregnancy rates across different age groups.
Main Methods:
- Sixty female participants were randomly assigned to receive either PRP or HRT.
- Participants were stratified into five age groups.
- Controlled ovarian stimulation, hormonal treatments, and embryo transfer were performed; endometrial thickness was measured before transfer.
Main Results:
- PRP therapy resulted in significantly higher endometrial thickness (p<0.001) compared to HRT.
- Clinical pregnancy rates were higher in the PRP group (63.33%) versus the HRT group (40%).
- Positive outcomes with PRP were particularly noted in younger age cohorts.
Conclusions:
- Platelet-rich plasma (PRP) therapy demonstrates potential for improving fertility outcomes.
- PRP therapy may offer advantages over conventional HRT, especially for younger women.
- Further investigation into PRP's mechanisms in reproductive medicine is warranted.
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