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Fluorescent covalent organic frameworks - promising bioimaging materials.

Chimatahalli Santhakumar Karthik1,2,3, Tina Skorjanc4, Dinesh Shetty2,3

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Fluorescent covalent organic frameworks (COFs) offer advanced bioimaging for living cells. These materials show potential for tracking biomolecules and sensing intracellular conditions like pH and ROS.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Fluorescent covalent organic frameworks (COFs) possess unique properties and tunable fluorescence, making them suitable for biological applications.
  • Recent advancements highlight their potential in imaging living cells.

Purpose of the Study:

  • To review recent progress in fluorescent COFs for bioimaging.
  • To discuss design strategies, applications, and future prospects of fluorescent COFs in living cell imaging.

Main Methods:

  • Overview of design strategies for fluorescent COFs with enhanced photostability, biocompatibility, and pH sensitivity.
  • Exploration of applications in cellular imaging, organelle targeting, and biomolecule tracking.
  • Examination of functionalization techniques for improved targeting and imaging.

Main Results:

  • Fluorescent COFs demonstrate utility in sensing intracellular pH and reactive oxygen species (ROS).
  • Functionalization enhances the targeting specificity and imaging capabilities of COFs.
  • These materials show promise for tracking specific biomarkers within living cells.

Conclusions:

  • Fluorescent COFs are highly promising for advanced bioimaging in living cells.
  • Further research is needed to overcome current challenges and fully realize their potential.
  • Continued development in functionalization and design will expand their applications in cellular studies.