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Casting a Wide NET? The Impact of Pancreatectomy on Neutrophil Extracellular Traps

Richard Zheng1, Richard A Burkhart2

  • 1Division of Surgical Oncology, Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Annals of Surgical Oncology
|March 4, 2024
PubMed
Abstract

No abstract available in PubMed .

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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