Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway.

Area of Science:

• Mitochondrial dynamics and cellular biology
• Biochemistry and molecular genetics

Background:

• Dynamin-Related Protein 1 (Drp1) regulates mitochondrial fission, impacting cell survival, proliferation, migration, and death.
• Drp1 exhibits distinct physiological roles in both normal and inflammatory conditions.
• Emerging evidence highlights Drp1's critical involvement in disease pathogenesis, positioning it as a potential therapeutic target.

Purpose of the Study:

• To review the structure and biological properties of Drp1.
• To summarize Drp1's role in inflammatory responses and cancer.
• To investigate therapeutic strategies targeting Drp1 in cancer treatment.

Main Methods:

• Literature review and synthesis of existing research on Drp1.
• Analysis of Drp1's involvement in mitochondrial pathways.
• Exploration of Drp1 targeting in cancer therapy.

Main Results:

• Drp1 influences diverse cellular processes and physiological states.
• Drp1 plays a significant role in inflammation and cancer development.
• Various methods for targeting Drp1 in cancer treatment have been explored.

Conclusions:

• Understanding Drp1's mechanisms is vital for developing therapies for mitochondrial diseases.
• Targeting Drp1 presents a promising avenue for treating inflammatory diseases and cancers.
• Further research into Drp1 pathways can advance therapeutic applications for a range of diseases.