Current methods for hyperpolarized [1-¹³C]pyruvate MRI human studies

Area of Science:

• Medical Imaging
• Metabolic Imaging
• Hyperpolarized MRI

Background:

• Hyperpolarized (HP) ¹³C MRI measures localized metabolism altered in diseases.
• Human studies have grown rapidly in the last decade due to improved HP agent preparation.
• ¹³C-pyruvate is the most common agent, crucial for studying glycolysis.

Purpose of the Study:

• To outline current successful practices for human HP ¹³C MRI studies.
• Focuses on [1-¹³C]pyruvate, a key metabolic tracer.
• To provide a comprehensive reference for the advancing field of metabolic imaging.

Main Methods:

• Covers HP ¹³C-pyruvate preparation methods.
• Details MRI system setup and calibration protocols.
• Explains data acquisition, image reconstruction, and analysis techniques.

Main Results:

• Identifies key components for successful HP ¹³C MRI studies.
• Summarizes published studies and current clinical practices.
• Discusses evidence gaps, strengths, and limitations of the modality.

Conclusions:

• Establishes a consensus on best practices for human HP ¹³C MRI.
• Aims to guide future research and development in metabolic imaging.
• Highlights the potential of HP ¹³C MRI for diagnosing and monitoring various diseases.