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Updated: Jul 13, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Postoperative Herpes Viral Infections in Neurosurgery - An Experience and Arguments for and against the Plausible
Sanjeev Kumar1, Debabrata Sahana, Lavlesh Rathore
1Department of Neurosurgery, DKS Post Graduate Institute and Research Center, Raipur, Chhattisgarh, India.
Background:
The literature contains several reports of herpes recrudescence after neurosurgery. We analyze our experience by vindicating or refuting the existing plausible hypotheses.
Material And Methods:
This is a retrospective review of all neurosurgical cases that developed postoperative herpes infection between January 2016 and June 2020.
Results:
Six patients developed herpes infection after vestibular schwannoma (VS) surgery. Other neurosurgical cases did not develop herpes infection. There were five females and one male, with a mean age of 44.1 years. Four out of six patients developed delayed facial palsy (DFP) and did not improve after antiviral treatment. Postoperative herpes infections were 0.2% among all operated patients, 3.07% among all cerebellopontine (CP) angle surgeries, and 5.6% among VS surgeries.
Conclusions:
To date, none of the plausible hypotheses satisfactorily addresses all aspects of viral recrudescence. The etiology may be multi-factorial, and in all cases of unexplained clinical deterioration, herpes infection needs consideration in the differential diagnosis.
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