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Published on: May 26, 2019
Synthetic Utilization of 2H-Heptafluoropropane: Ionic 1,4-Addition to Electron-Deficient Carbon-Carbon Unsaturated
Yusuke Higashi1, Kotono Shima1, Mikiya Suzuki1
1Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan.
Abstract:
We have found a novel method for introducing heptafluoro-2-propyl CF(CF3)2 groups into carbon-carbon unsaturated bonds via a nucleophilic reaction using 2H-heptafluoropropane as the source of CF(CF3)2 groups. The reaction involves the nucleophilic addition of a heptafluoro-2-propyl anion, generated by treating 2H-heptafluoropropane with a fluoride ion, to various electron-deficient unsaturated compounds. This allows the easy synthesis of various aliphatic compounds containing heptafluoro-2-propyl groups.
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