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Tuneable hydrogel patterns in pillarless microfluidic devices.

Claudia Olaizola-Rodrigo1,2, Sujey Palma-Florez3,4, Teodora Ranđelović1,5,6

  • 1Tissue Microenvironment (TME), Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain. iochgar@unizar.es.

Lab on a Chip
|March 6, 2024
PubMed
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This summary is machine-generated.

This study introduces a novel plasma surface treatment for creating pillarless organ-on-chip devices. This innovation enables more precise control over shear stress and complex geometries for advanced biomimetic models.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Tissue Engineering

Background:

  • Organ-on-chip (OOC) technology aims to replace animal testing and advance personalized medicine.
  • Hydrogels in microfluidic devices offer biomimetic 3D scaffolds but face limitations with physical pillars.
  • Pillars in OOC devices can disrupt fluid flow and alter mechanical environments.

Purpose of the Study:

  • To develop a pillarless OOC device fabrication method using plasma surface treatment.
  • To enable arbitrary geometries for precise shear stress control and biomimetic models.
  • To overcome limitations of existing OOC technologies regarding geometry and fluid dynamics.

Main Methods:

  • Plasma surface treatment for creating abutment-free cell culture chambers.

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  • Computational simulations to analyze shear stress distributions in various geometries.
  • Fabrication of pillarless devices with complex patterns.
  • Development of a blood-brain barrier (BBB) model using the new technique.

    • Main Results:

    • Demonstrated precise shear stress control in pillarless OOC devices with arbitrary geometries.
    • Successfully recreated an uninterrupted endothelial barrier for a BBB model.
    • Validated the versatility and reliability of the new fabrication technique.
    • Showcased the potential for complex, adaptable OOC geometries and controlled fluid flow.

    Conclusions:

    • The developed plasma surface treatment method overcomes limitations of pillar-based OOC devices.
    • Pillarless OOC models offer enhanced control over mechanical environments and biomimicry.
    • This technology facilitates the creation of more versatile, reliable, and physiologically relevant experimental models.