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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Related Experiment Video

Updated: Jul 1, 2025

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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[Epigenetic modifications and cardiovascular diseases : new Eldorado].

Olivier Emery1, David Nanchen2, Jonviea Chamberlain3

  • 1PhD, Bioinformaticien, chargé de recherche, Département promotion de la santé et préventions, Unisanté, 1011 Lausanne.

Revue Medicale Suisse
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Epigenetic signatures, which reflect environmental impacts on cardiovascular disease (CVD) risk, show promise for clinical applications. Further research is needed to translate these epigenetic insights into routine CVD diagnosis and patient monitoring.

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Area of Science:

  • Epigenetics and Environmental Health
  • Cardiovascular Disease (CVD) Research
  • Biomarker Discovery

Context:

  • Cardiovascular disease (CVD) risk is significantly influenced by environmental factors.
  • Epigenetic modifications are known to be affected by both environment and disease processes.
  • Epigenetic signatures offer a method to characterize disease-associated epigenetic changes.

Purpose:

  • To explore the potential of epigenetic signatures as biomarkers for cardiovascular disease (CVD).
  • To highlight the role of environmental influences on epigenetic modifications relevant to CVD.
  • To discuss the clinical applications of epigenetic signatures in CVD diagnosis, prognosis, and monitoring.

Summary:

  • Epigenetic signatures are identifiable patterns of epigenetic modifications linked to specific diseases or risk factors.
  • These signatures can serve as a summary of epigenetic alterations influenced by environmental exposures and disease development.
  • While successful in oncology, the clinical application of epigenetics in CVD requires further investigation.

Impact:

  • Establishes the foundation for developing novel epigenetic biomarkers for cardiovascular health.
  • Highlights the critical interplay between environment, epigenetics, and cardiovascular disease.
  • Underscores the need for continued research to realize the clinical utility of epigenetic signatures in managing CVD.