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Updated: Mar 6, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
[N-of-1 trials forstatin intolerance : feasibility in clinical practice]
Léonore Diezi1, Thierry Buclin2, David Nanchen3
1Service de pharmacologie clinique, Centre hospitalier universitaire vaudois, 1011 Lausanne.
None:
N-of-1 trials allow for an individualized assessment of statin tolerance in patients reporting adverse effects. This article presents six patients in whom these tests showed no significant difference between the statin and the comparator, suggesting a nocebo effect. All patients chose to resume treatment. These rigorous, personalized, controlled therapeutic tests enhanced treatment adherence. Despite their high level of evidence, they remain underused. This case series illustrates their feasibility in clinical practice and their value in optimizing patient management.
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