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Updated: Aug 10, 2026

Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
Fabrication and characterization of salidroside W/O/W emulsion with sodium alginate
Qian Zhang1, Yu-Qiao Wang2, Lin Li2
1College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, China.
Abstract:
Salidroside (Sal), the main bioactive substance in Rhodiola rosea, is a promising functional food component with a wide range of pharmacological effects, but its biological activity is challenging to sustain due to its short half-life, low oral bioavailability, and susceptibility to environmental factors. The aim of this study was to investigate the effect of sodium alginate (SA) concentration on the construction of W/O/W emulsion in the protection of Sal. With the escalation of SA concentrations, the range of droplet size distribution was smaller and the droplets were more uniform. When the concentration of SA was 2 %, the average droplet size reached 9.1 ± 0.1 μm, and the encapsulation efficiency of Sal was 77.8 ± 1.8 %. Moreover, the double emulsion with 2 % SA was the most stable for 28 days at 4 °C since the oil droplets were embedded in the network structure of SA.
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