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Water-enabling strategies for asymmetric catalysis.

Gang Wen1, Xiaoming Feng1, Lili Lin1

  • 1Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China. lililin@scu.edu.cn.

Organic & Biomolecular Chemistry
|March 7, 2024
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Summary
This summary is machine-generated.

Water is a green solvent that enhances chemical reactions. This review covers water-enabled strategies in catalytic asymmetric synthesis over the last decade, highlighting how water influences reaction outcomes.

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Area of Science:

  • Green Chemistry
  • Organic Synthesis
  • Catalysis

Background:

  • Water is an abundant, eco-friendly solvent with mild properties.
  • Water demonstrates unique capabilities in catalytic asymmetric synthesis.
  • Previous reviews highlight water's positive impact on asymmetric synthesis.

Purpose of the Study:

  • To summarize water-enabled strategies in asymmetric synthesis from the last decade.
  • To elucidate the mechanisms by which water influences chemical reactions.
  • To provide insights into optimizing reactions using water as a solvent or reagent.

Main Methods:

  • Literature review of water-enabling strategies in asymmetric synthesis.
  • Analysis of studies focusing on water's effects on reaction rates and selectivity.
  • Categorization of water's influence based on hydrophobic, hydrogen bonding, and protonation effects.

Main Results:

  • Water accelerates reaction rates and improves stereoselectivities (diastereo- and enantioselectivities).
  • Water can initiate reactions and diversify chemo-, diastereo-, or enantioselectivities.
  • Specific examples illustrate water's multifaceted roles in various asymmetric transformations.

Conclusions:

  • Water is a versatile and advantageous medium for catalytic asymmetric synthesis.
  • Understanding water's effects allows for the development of more efficient and selective synthetic methods.
  • Water-based strategies offer a sustainable approach to complex molecule synthesis.