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Temporal progression of pancreatic cancer computed tomography findings until diagnosis: A large-scale multicenter
Masanori Gonda1, Atsuhiro Masuda1, Takashi Kobayashi1
1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
United European Gastroenterology Journal
|March 7, 2024
Summary
Focal parenchymal atrophy is the earliest sign of pancreatic cancer, appearing years before diagnosis. Main pancreatic duct dilatation also indicates cancer but appears later. These findings aid early detection.
Area of Science:
- Oncology
- Radiology
- Gastroenterology
Background:
- Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation are early indicators of pancreatic ductal adenocarcinoma (PDAC).
- Limited data exists on the temporal progression of these PDAC signs due to prior study constraints.
Purpose of the Study:
- To determine the frequency of suspicious PDAC findings on CT scans.
- To delineate the temporal progression of these findings before PDAC diagnosis.
Main Methods:
- A multicenter retrospective study analyzed CT scans from 320 PDAC patients (2015-2021) with scans ≥6 months pre-diagnosis.
- Investigated the temporal evolution of suspicious PDAC findings on computed tomography (CT).
Main Results:
- Suspicious findings occurred in 47.8% of patients; focal parenchymal atrophy (26.6%) and MPD dilatation (11.3%) were most common.
- Focal parenchymal atrophy appeared earliest (2.7 years pre-diagnosis), followed by MPD dilatation (1.1 years).
- Atrophy progressed to tumor occupation by diagnosis; MPD dilatation continued to progress.
Conclusions:
- Temporal progression of focal parenchymal atrophy is the earliest CT sign of PDAC.
- These insights are crucial for improving early PDAC detection strategies.
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