Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer
Lin Tan1,2, Yang Pan3, Qing-Ying Zeng1,2
1School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, Hangzhou, Zhejiang 310024, People's Republic of China.
Abstract:
Herein, we report the C-H cyanation of indoles via a palladium-catalyzed directed C-CN activation reaction using aryl nitrile as a cyano source. The employment of the phenoxy-oriented group is the key to the cleavage of the C-CN bond. This protocol features a broad substrate scope, good efficiency, and high regioselectivity. Furthermore, the practical application of this protocol was showcased in the late-stage functionalization and synthesis of indole derivatives, which were derived from drugs and natural products, through the process of cyanation.
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