Recent advance on microextraction sampling technologies for bioanalysis

Area of Science:

• Analytical Chemistry
• Biochemistry
• Materials Science

Background:

• Biological samples often contain target substances at very low concentrations.
• Complex biological matrices pose significant challenges for accurate analysis.
• Effective sample preparation is crucial for successful bioanalysis.

Purpose of the Study:

• To review recent advancements in microextraction sampling technologies for bioanalysis.
• To discuss progress in microextraction media and sampling strategies.
• To highlight current challenges and future trends in the field.

Main Methods:

• Review of literature on microextraction media preparation.
• Summary of microextraction sampling strategies, including in-vivo, in-vitro, and microdialysis.
• Analysis of developments in aptamer-functionalized materials, molecularly imprinted polymers, carbon-based materials, metal-organic frameworks, and covalent organic frameworks.

Main Results:

• Significant progress has been made in developing efficient microextraction media.
• Miniaturization and automation of sample preparation methods are key developments.
• Diverse microextraction sampling strategies are being employed for various bioanalytical needs.

Conclusions:

• Microextraction sampling technologies are vital for overcoming challenges in bioanalysis.
• Continued innovation in materials and strategies will drive the field forward.
• Future trends include further automation and development of highly selective extraction media.