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Updated: Jul 1, 2025
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Immune landscape and response to oncolytic virus-based immunotherapy
Chaolong Lin1,2, Wenzhong Teng1,2, Yang Tian1,2
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Frontiers of Medicine
|March 7, 2024
Summary
Oncolytic virus (OV) immunotherapy shows promise for cancer treatment by targeting tumors. Overcoming the tumor microenvironment
Area of Science:
- Oncology
- Immunotherapy
- Virology
Background:
- Oncolytic virus (OV)-based immunotherapy is a promising cancer treatment strategy.
- The tumor microenvironment (TME) often suppresses immune responses, hindering OV effectiveness.
- Overcoming TME-induced immune resistance is critical for successful OV therapy.
Purpose of the Study:
- To review the potential of OV immunotherapy in modulating the TME.
- To explore how OVs can enhance antitumor immune responses.
- To discuss strategies for optimizing OV delivery and efficacy.
Main Methods:
- Review of current literature on OV immunotherapy and TME interactions.
- Analysis of OV roles in targeting immune cells (dendritic cells, T cells, NK cells, macrophages).
- Examination of OV-mediated TME alterations (angiogenesis inhibition, fibrosis reduction).
Main Results:
- OVs can modulate the immune landscape within the TME.
- OVs can target and influence various immune cell populations.
- Strategies exist to improve OV drug delivery and immunotherapy efficiency.
Conclusions:
- OV immunotherapy holds significant potential for cancer treatment.
- Modulating the TME is key to enhancing OV efficacy.
- Further optimization of OV-based strategies is crucial for clinical success.
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