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Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
Comprehensive bioinformatics analysis and systems biology approaches to identify the interplay between COVID-19 and
Daisong Li1, Ruolan Chen1, Chao Huang1
1Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Insights
This study identified common genes and molecular mechanisms linking coronavirus disease 2019 (COVID-19) and pericarditis. Eight key genes were highlighted, offering new research avenues for understanding COVID-19 associated pericarditis.
Area of Science:
- Immunology
- Genetics
- Computational Biology
Background:
- Growing evidence links coronavirus disease 2019 (COVID-19) to increased risks of pericarditis.
- The underlying molecular mechanisms connecting COVID-19 and pericarditis remain largely unknown.
- Investigating the genetic basis is crucial for understanding this association.
Purpose of the Study:
- To elucidate the molecular mechanisms of COVID-19 associated pericarditis at the gene level.
- To identify common genes and pathways involved in both conditions.
- To utilize bioinformatics for a comprehensive genetic analysis.
Main Methods:
- Collected and intersected genes associated with COVID-19 and pericarditis.
- Performed gene ontology, pathway enrichment, and protein-protein interaction analyses.
- Constructed interaction networks and conducted immune infiltration analysis.
Main Results:
- Identified 313 common genes between COVID-19 and pericarditis.
- Eight hub genes (IL-1β, CD8A, IL-10, CD4, IL-6, TLR4, CCL2, PTPRC) were identified.
- Revealed a common gene interaction network and predicted related transcription factors, miRNAs, and drugs.
Conclusions:
- Established a common gene interaction network for COVID-19 and pericarditis.
- Highlighted key functional pathways and hub genes for further investigation.
- Provided potential therapeutic targets and insights into COVID-19 associated pericarditis.
Background:
Increasing evidence indicating that coronavirus disease 2019 (COVID-19) increased the incidence and related risks of pericarditis and whether COVID-19 vaccine is related to pericarditis has triggered research and discussion. However, mechanisms behind the link between COVID-19 and pericarditis are still unknown. The objective of this study was to further elucidate the molecular mechanisms of COVID-19 with pericarditis at the gene level using bioinformatics analysis.
Methods:
Genes associated with COVID-19 and pericarditis were collected from databases using limited screening criteria and intersected to identify the common genes of COVID-19 and pericarditis. Subsequently, gene ontology, pathway enrichment, protein-protein interaction, and immune infiltration analyses were conducted. Finally, TF-gene, gene-miRNA, gene-disease, protein-chemical, and protein-drug interaction networks were constructed based on hub gene identification.
Results:
A total of 313 common genes were selected, and enrichment analyses were performed to determine their biological functions and signaling pathways. Eight hub genes (IL-1β, CD8A, IL-10, CD4, IL-6, TLR4, CCL2, and PTPRC) were identified using the protein-protein interaction network, and immune infiltration analysis was then carried out to examine the functional relationship between the eight hub genes and immune cells as well as changes in immune cells in disease. Transcription factors, miRNAs, diseases, chemicals, and drugs with high correlation with hub genes were predicted using bioinformatics analysis.
Conclusions:
This study revealed a common gene interaction network between COVID-19 and pericarditis. The screened functional pathways, hub genes, potential compounds, and drugs provided new insights for further research on COVID-19 associated with pericarditis.
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