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The First Report of Candida Auris Infection in Vietnam
Thong Dang-Vu1, Dung Lam-Quoc1, Ngoc Duong-Minh1,2
1Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Abstract:
Infection caused by Candida auris ha C. auris s rapidly become a global health threat. C. auris created a significant healthcare burden due to various complicating factors, including misidentification by commercial identification methods, potent antifungal resistance, high mortality rates and the possibility of nosocomial outbreaks through direct contact. In Vietnam, there are currently no clinical reports on C. auris infections. Here, we present four clinical cases of C. auris infections in the Department of Pulmonary Medicine of Cho Ray Hospital in southern Vietnam. Through this report, we aim to highlight the attention to the emergence of C. auris in Vietnam. Further research on C. auris infections is warranted, focusing on newly observed clinical characteristics present in all cases in this report, including hypoalbuminaemia and corticosteroid usage. Moreover, one case of resistance to amphotericin B has been identified, possibly due to prior exposure to this antifungal agent.
Learning Points:
Further research on Candida auris infections is warranted, focusing on newly observed clinical features present in all cases in this report, including hypoalbuminaemia and corticosteroid use during hospitalisation.While Candida auris remains susceptible to commonly used antifungal drugs, one case of resistance to amphotericin B has been documented, possibly due to prior exposure to this antifungal agent.
Insights
This study reports the first clinical cases of Candida auris (C. auris) in Vietnam, highlighting its emergence as a global health threat. The findings emphasize the need for increased surveillance and research into C. auris infections in the region.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Candida auris (C. auris) is an emerging global health threat causing significant healthcare burdens.
- Complicating factors include misidentification, antifungal resistance, high mortality, and nosocomial spread.
- No prior clinical reports of C. auris infections existed in Vietnam.
Purpose of the Study:
- To report the first four clinical cases of C. auris infections in Vietnam.
- To raise awareness regarding the emergence of C. auris in the Vietnamese healthcare setting.
- To highlight specific clinical characteristics observed in these cases.
Main Methods:
- Retrospective case series analysis of four patients diagnosed with C. auris infections.
- Clinical data collection including patient demographics, treatment, and outcomes.
- Antifungal susceptibility testing was performed.
Main Results:
- Four cases of C. auris infection were identified in the Department of Pulmonary Medicine at Cho Ray Hospital.
- Common clinical features included hypoalbuminemia and corticosteroid use.
- One case exhibited resistance to amphotericin B, potentially linked to prior exposure.
Conclusions:
- The emergence of C. auris in Vietnam necessitates heightened clinical and research attention.
- Hypoalbuminemia and corticosteroid use are notable clinical features associated with C. auris infections in this cohort.
- While generally susceptible, documented amphotericin B resistance underscores the importance of monitoring antifungal susceptibility patterns.
