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Peripheral artery disease: an underdiagnosed condition in familial hypercholesterolemia? A systematic review
Elisa Acitelli1, Alexis F Guedon2, Sara De Liguori1
1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Familial hypercholesterolemia (FH) patients show a wide range of peripheral artery disease (PAD) prevalence and incidence. More research is needed to understand PAD in FH, especially with new lipid-lowering treatments.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Epidemiology
Background:
- Familial hypercholesterolemia (FH) is a common inherited disorder causing high LDL-cholesterol and early atherosclerosis.
- While FH is linked to coronary and carotid artery disease, its association with peripheral artery disease (PAD) is less clear.
Conclusions:
- There is a limited body of research on PAD in FH patients.
- Further investigation is crucial for understanding peripheral vascular disease in FH and optimizing patient management, especially with emerging lipid-lowering therapies.
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