Contrast-free left atrial appendage occlusion in patients using the LAMBRE™ device

Area of Science:

• Cardiology
• Medical Imaging
• Interventional Procedures

Background:

• Left atrial appendage closure (LAAC) procedures are increasingly optimized with advanced imaging techniques.
• Contrast-free approaches guided by echocardiography are emerging but lack extensive data.
• This study evaluates the LAMBRE LAAC device in a contrast-free setting.

Purpose of the Study:

• To assess the safety and feasibility of contrast-free LAAC using the LAMBRE device.
• To analyze procedural outcomes and complications in a real-world patient cohort.
• To contribute data on echocardiography-guided LAAC without contrast dye.

Main Methods:

• A multicenter retrospective analysis (BoBoMa-Registry) of 118 patients undergoing LAAC with LAMBRE devices.
• Procedures were performed without contrast dye, guided solely by echocardiography.
• Baseline characteristics, procedural details, and complications were evaluated.

Main Results:

• High device success rate of 97.5% was achieved in elderly patients with high thromboembolic and bleeding risks.
• Mean procedural time was 47.2 minutes with a mean radiation dose of 4.75 Gy*cm².
• Periprocedural complications occurred in 6.8% of cases, with no relevant peri-device leakage observed.

Conclusions:

• Echocardiography-guided, contrast-free LAAC with the LAMBRE device is a safe and feasible procedure.
• The study supports the use of this technique in selected patient populations.
• Further prospective studies comparing devices and imaging modalities are recommended.