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Updated: Jul 1, 2025

Cellular Redox Profiling Using High-content Microscopy
Published on: May 14, 2017
Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases
Mirza Ahmar Beg1, Minqi Huang2, Lance Vick3
1Versiti Blood Research Institute, Milwaukee, WI 53226, USA.
None:
Accumulating evidence highlights the pivotal role of mitochondria in cardiovascular diseases (CVDs). Understanding the molecular mechanisms underlying mitochondrial dysfunction is crucial for developing targeted therapeutics. Recent years have seen substantial advancements in unraveling mitochondrial regulatory pathways in both normal and pathological states and the development of potent drugs. However, specific delivery of drugs into the mitochondria is still a challenge. We present recent findings on regulators of mitochondrial dynamics and reactive oxygen species (ROS), critical factors influencing mitochondrial function in CVDs. We also discuss advancements in drug delivery strategies aimed at overcoming the technical barrier in targeting mitochondria for CVD treatment.
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